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The purpose of our research is to elucidate molecular mechanisms that regulate cell-cell communication during development. Using the Drosophila melanogaster model system we study how cells reproducibly and selectively interpret information within a complex developing field. We focus on genes that modulate the function of TGF-β superfamily of growth and differentiation factors. We are interested in how extracellular availability of TGF-β factors is regulated in time and space, and what is the role of the cell surface in modulating local activation of TGF-β-type signaling. Our goal is to provide genetic and biochemical descriptions of how signaling is modulated outside the cell and how it has been adapted for different roles during development and evolution.
